Endocrine Abstracts

Background: Adipose tissue dysfunction, such as adipocyte hypertrophy and secretion of pro-inflammatory cytokines, develops in obese subjects and goes hand in hand with obesity-related complications, especially insulin resistance (IR) and systemic inflammation. The exact mechanisms underlying adipose tissue dysfunction and consequently the obesity-related complications are not yet fully understood.Aim: Investigate the association between systemic IR and ...

Objective: Testosterone levels are decreased in male obesity, the mechanism of which is incompletely understood. The aim of this study was to explore determinants affecting the feedback mechanism of the hypothalamic–pituitary–gonadal axis in male obesity and type 2 diabetes (DM2), such as aromatase expression and lipotoxicity.Materials and methods: Circulating levels of testosterone were quantified (<1000 h with LC–MS/MS) in 37 middle-...

Background and aim: Adipose and muscle tissue dysfunction are associated with obesity-related complications, especially insulin resistance (IR) and inflammation, which improve after weight loss. The underlying mechanisms are however not yet fully understood. This study investigates changes in systemic and regional markers of IR and inflammation during weight loss in subjects with obesity.Materials and methods: Twenty subjects with obesity (age 49±10...

Aims: Emerging data indicate that an impaired release of adipose tissue-derived adipokines could play a pivotal role in the development of non-alcoholic fatty liver disease (NAFLD). We aimed to evaluate whether circulating levels or visceral adipose tissue (VAT) expression of recently described adipokines associate with the histopathological disease severity and thus may contribute to the progression of pure fatty liver into an inflammatory and insulin resistant NASH status.</...